Blar i forfatter "Govinden, Usha"

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    • Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa 

      Janice, Jessin; Agyepong, Nicholas; Owusu-Ofori, Alex; Govinden, Usha; Essack, Sabiha; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Pedersen, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-17)
      Two novel bla<sub>DIM-1</sub>- or bla<SUB>IMP-1</SUB>-containing genomic islands (GIs) were discovered by whole-genome sequence analyses in four extensively drug-resistant (XDR) <i>Pseudomonas aeruginosa</i> isolates from inpatients at a tertiary hospital in Ghana. The strains were of sequence type 234 (ST234) and formed a phylogenetic clade together with ST111, which is recognized as a global ...

    • Faecal colonization of E. coli and Klebsiella spp. producing extended-spectrum beta-lactamases and plasmid-mediated AmpC in Mozambican university students 

      Chirindze, Lourenco Marcos; Zimba, Tomas F.; Sekyere, John Osei; Govinden, Usha; Chenia, Hafizah Y.; Sundsfjord, Arnfinn; Essack, Sabiha Y.; Simonsen, Gunnar Skov (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-08)
      <p><i>Background</i>: In recent years, the world has seen a surge in Enterobacteriaceae resistant to broad-spectrum beta-lactam antibiotics due to the production of extended-spectrum beta-lactamases (ESBLs) or plasmid-mediated AmpC (pAmpC) enzymes. Data on the epidemiology of cephalosporin-resistant Enterobacteriaceae in Sub-Saharan Africa are still limited.</p> <p><i>Methods</i>: Two hundred ...

    • Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital 

      Agyepong, Nicholas; Govinden, Usha; Owusu-Ofori, Alex; Amoako, Daniel Gyamfi; Allam, Mushal; Janice, Jessin; Pedersen, Torunn Annie; Sundsfjord, Arnfinn; Essack, Sabiha (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
      <p><i>Objectives - </i>This study delineated the clonal lineages, antibiotic resistome and plasmid replicon types in multidrug-resistant <i>K. pneumoniae</i> isolates from a teaching hospital in Ghana. <p><i>Methods - </i>Identification and antibiotic susceptibility testing were done using the MALDI-TOF MS and Vitek-2 automated system. Genomic DNA extraction was carried out using the NucliSens ...

    • High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique 

      Estaleva, Calvina E.L.; Zimba, Tomas F.; Sekyere, John Osei; Govinden, Usha; Chenia, Hafizah Y.; Simonsen, Gunnar S.; Haldorsen, Bjørg; Essack, Sabiha Y.; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-06)
      Background: Epidemiological data of cephalosporin-resistant Enterobacterales in Sub-Saharan Africa is still restricted,and in particular in Mozambique. The aim of this study was to detect and characterize extended-spectrum β-lactamase (ESBL) - and plasmid-mediated AmpC (pAmpC)-producing clinical strains of Escherichia coli at Maputo Central Hospital (MCH), a 1000-bed reference hospital in Maputo, ...

    • β-lactam and fluoroquinolone resistance in Enterobacteriaceae from imported and locally-produced chicken in Mozambique 

      Faife, Sara Lino; Zimba, Tomas; Sekyere, John Osei; Govinden, Usha; Chenia, Hafizah Y.; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Essack, Sabiha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-31)
      Introduction: Plasmid-mediated resistance to β-lactam and fluoroquinolone antibiotics was investigated in Enterobacteriaceae isolated from retailed frozen chickens from Brazil, South Africa and Mozambique.<p> <p>Methodology: Carcass swabs and the liquid thaw of 33 chickens from each of the three countries constituted the total sample size of 198. Isolates were identified by biochemical tests, ...